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Nle-AngIV also increased spine numbers to 32 spines/50m, but to a lesser extent than Dihexa

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A large number of patients lose a few percent of body weight over a period of months, enough in some cases to restore ovulation

The mechanistic difference translates directly to side-effect profiles: cagrilintide causes nausea and vomiting in 3040% of subjects during dose titration (similar to GLP-1 agonists), while tesofensine produces insomnia, dry mouth, and increased heart rate in 2035% due to its sympathomimetic effects