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This hypothetical adverse effect, although not clinically reported until now, is analogous to the hypothalamic-pituitary axis suppression seen with long-term use of systemic corticosteroids Exacerbation of Helicobacter pylori associated peptic ulcers: Helicobacter pylori is known to feed on macrophages and neutrophils abundant at the site of inflammation caused by the ulcer

[DOI] [PubMed] [Google Scholar] [94].Schmitz H, Fromm M, Bentzel CJ, Scholz P, Detjen K, Mankertz J, et al

Most drug molecules enter the brain by paracellular or transcellular passive diffusion, though passive diffusion is limited in the brain compared to other tissues

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