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Cancer Med 9(10):34893499 Majewska E, Mrquez J, Albrecht J, Szeliga M (2019) Transfection with GLS2 glutaminase (GAB) sensitizes human glioblastoma cell lines to oxidative stress by a common mechanism involving suppression of the PI3K/AKT pathway

On the other hand, CircLARP1B increases fatty acid production, thus enhancing cellular metastasis and lipid buildup in HCC [43]

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Also, MTX administration leads to inflammatory cascades involving the activation of NF-B, with increased expression of pro-inflammatory cytokines such as IL-6 and TNF-, followed by activation of the JAK/ STAT3 signaling (RFd et al