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The primary hormones produced by the ovaries are estrogens , which include estradiol, estriol, and estrone

Conversely, decreased GH/IGF-1 signaling has also been shown to extend longevity in a wide variety of species such as worms, fruit flies, mice, and yeast (468), thus raising the question of whether decreased activity of the GH/IGF-1 axis might be beneficial for human longevity

Pregnant or nursing women should avoid DSIP due to the lack of safety data in these populations

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