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The mechanisms by which copper contributes to disease pathogenesis form an intricate network, centrally involving copper dyshomeostasis and its consequences, including oxidative stress (Rodriguez et al., 2024), protein aggregation (Zou et al., 2021), immune escape (Yi et al., 2022), angiogenesis (Tao et al., 2021)

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Tumor hypoxia: Classification, detection, and its critical role in cancer progression

Notably, LASSS displayed additional functions to promote receptor binding-affinity and nitration resistance of HGF in a dose-dependent manner, that is high-dose LASSS in excess of a 1:4000 molar ratio to HGF, as revealed by biochemical assays after wash-out of un-reacted free LASSS (Figure 2a-d)