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Crotonylation enhances the stability of these enzymes by altering protein conformation or interfering with the ubiquitin-dependent degradation pathway to produce metabolic abnormalities in the body

Genetic ablation of astrocytic Cx43 reduces neuronal hyperactivity and mechanical allodynia in rodent models of neuropathic pain 500

Among the pathways identified, arginine and proline metabolism, methionine metabolism, glycine and serine metabolism, urea cycle metabolism, and purine metabolism have been recurrently associated with these ocular conditions, highlighting potential commonalities in their metabolic underpinnings