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40 A Cochrane meta-analysis of 13 RCTs found that SMO was effective in treating alcohol withdrawal syndrome and preventing relapses in patients who were previously detoxified

[25] Tretinoin, the all-trans retinoic acid isomer, diffuses through the stratum corneum and binds intracellular retinoic acid receptors (RAR-, , ), forming heterodimers with RXR that trans-activate genes governing keratinocyte differentiation, desmosomal degradation, and collagen synthesis

This process depends on AhR upregulating multidrug resistance-associated protein 1 (Mrp1) and the subsequent triggering of glutathione depletion and lipid peroxidation (Zhang et al., 2013)