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Limited data on buccal use suggests superior progesterone absorption but with a pharmacokinetic profile that may be more similar to oral use as opposed to transdermal or vaginal use

Future studies should optimize these management strategies and strengthen multimodal interventions to reduce complication rates and improve patient quality of life

Unfortunately, while antidiabetics and antihyperlipidemic help in CKD management, they are excreted by the kidneys and have a high risk of drug accumulation in renal cells which significantly contributes to CKD [221]

5,7-Dihydroxy-4-methylcoumarin modulates the JNK/FoxO1 signaling pathway to attenuate cisplatin-induced ototoxicity by suppressing oxidative stress and apoptosis in vitro