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It was originally developed in Russia in the 1980s and later approved there as a prescription nootropic drug

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

10.1074/jbc.M108777200 J

The glutathione s-transferase PtGSTF1 improves biomass production and salt tolerance through regulating xylem cell proliferation, ion homeostasis and reactive oxygen species scavenging in Poplar