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These conditions do not always reflect how the peptide is used in practice

One way of assessing drug synergy consists of combining drugs at half of their IC50 concentration for a two-drug combination, and one-third of their IC50 concentration for a three-drug combination (39, 70)

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In fact, one study found that peoples bodies absorbed about 49% of a 1-mcg dose of cyanocobalamin, compared to 44% of the same dose of methylcobalamin ( Conversely, another study comparing the two forms reported that about three times as much cyanocobalamin was excreted through urine, indicating that methylcobalamin may be retained better within your body ( However, some research suggests that differences in bioavailability between the two forms may be insignificant and that absorption could be influenced by factors such as age and genetics ( Unfortunately, recent research directly comparing these two forms of vitamin B12 is limited