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In chronic pain and depression, chronic exposure to stress is a common factor that may produce long-lasting changes (i.e., maladaptive neuroplasticity) in highly sensitive brain areas such as the prefrontal cortex and the hippocampus and in their functional connections, which may underlie the cognitive and behavioral impairments accompanying these conditions (Teffer and Semendeferi, 2012

doi: 10.1097/JCMA.0000000000000389 102 CoplandJAMarlowLAKurakataSFujiwaraKWongAKKreinestPAet al

More recent research has shown that carnitine can be beneficial for both hypothyroidism and hyperthyroidism, with a decreased concentration of carnitine found in the skeletal muscles of people with both thyroid conditions

Ravindranathan P, Lee TK, Yang L, Centenera MM, Butler L, Tilley WD, et al