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Modi Memorial Lecture Oration Award 2025 delivered by the author during the ICAAICON 2025 Conference (an official annual conference of Indian College of Allergy , Asthma , and Applied Immunology) held at Shri Atal Bihari Vajpayee Scientific Convention Centre , King Georges Medical University , UP , Lucknow

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In stressed neutrophils, during an oxidative burst, glycolysis is shifted to the PPP, allowing the neutrophils to promptly mount a first line of defense against pathogens, using the generated NADPH for redox signaling ( 5.1.4 Oxidative phosphorylation Despite possessing intact mitochondria and a functional TCA cycle, mature neutrophils exhibit minimal reliance on mitochondrial respiration for their energy production (Rodrguez-Espinosa et al., 2015), since the inhibition of mitochondrial respiration had no impact on ATP generation in mature neutrophils (Maianski et al., 2004)