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Laminin-5 and MMP upregulation TB4 induces expression of matrix metalloproteinases (MMP-2, MMP-9) that remodel extracellular matrix during healing (Malinda 1999 J Invest Dermatol)

GGT (1, 5, or 10 U/mL) was added to the solution of BEAGA/ApoE-PDHD (2 mg) in 1 mL of PBS solution

As compared to the vehicle control, thapsic acid pre-incubation resulted in no apparent change in the ability of GDAP1 to bind 4HNE effect ( Figure 5D )