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SUSTAIN 9: Ozempic injection as an add-on to SGLT-2i MET/SU 6 Study design: 30-week, multinational, randomized, double-blind, parallel-group, placebo-controlled trial evaluating the efficacy and safety of adding Ozempic injection 1 mg to SGLT-2i metformin/sulfonylurea vs SGLT-2i + placebo metformin/sulfonylurea

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Standard Dosing Parameters Primary Application Dosing 1-2 mg daily 2-3 mg daily or 2 mg 2-3x per week 1-2 mg daily (injectable or topical) 2-5 mg daily under medical supervision Clinical studies used 0.3 mg/mL injections, while systemic wound healing in animal studies used approximately 1.1 mg/kg body weight (translating to ~75 mg total for humans in divided doses)