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Description

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

Neurodegenerative diseases are primarily driven by oxidative stress and inflammation

Methods: Retrospective study of patients with cirrhosis and ascites from a single quaternary centre from Apr 2020 to Mar 2021 identified patients who fulfilled the 2015 International Ascites Club (IAC) diagnosis of AKI

While the half-life of Nr1i3 mRNA is approximately 6.6h, the half-life of CAR protein remains unknown and could be investigated in primary hepatocytes in future experiments (75)