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doi: 10.1016/j.parkreldis.2021.01.004 109 KoshimoriY.SeguraB.ChristopherL.LobaughN.Duff-CanningS.MizrahiR.et al

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As the folate promotes the oligodendrocyte survival and myelination through DHFR-AMPK axis [51], therefore, folate deficiency, by impairing this DHFR-AMPK axis, can promote MS development or progression by negatively affecting oligodendrocyte survival and myelin production