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In clinical settings, pegloticase and SEL-212 formulations, combined with immunomodulators (e.g., methotrexate/sirolimus), suppress anti-drug antibody formation to maintain uricase activity, achieving long-term uric acid control and tophus resolution

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In contrast, caspase 3 activation, a marker for apoptotic activation, by AQ-QI and DEAQ-QI was higher without BSO pre-treatment ( Figure 4 )

GSH is abundantly synthesized in red blood cells, and the reductive recycling of GSSG by GSR is particularly important for prolonging their life span