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Certain antihistamines notably cimetidine and promethazine have been shown to actually reduce DAO activity with prolonged use, potentially worsening the underlying deficiency over time

L-Cysteine is an amino acid that serves as a building block for glutathione production

Concurrent administration of penicillines, cephalosporines, quinolones and cycloserine

Interactions with Benzodiazepines and Other CNS Depressants Inform patients and caregivers that potentially fatal additive effects may occur if hydrocodone bitartrate and acetaminophen tablets are used with benzodiazepines and other CNS depressants, including alcohol (e.g., non-benzodiazepines, sedative/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids [gabapentin or pregabalin], and other opioids), and not to use these concomitantly unless supervised by a healthcare provider (see WARNINGS and PRECAUTIONS, Drug Interactions)