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While side effects of GH administration in older adults include edema, arthralgias, and elevated blood glucose, data regarding the possible long-term effects on risk of fractures, cancer, cardiovascular disease, life expectancy, and mortality are lacking

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The relationship between growth hormone, aging, and optimal function continues to be an active area of investigationwith both promise and important cautions

Key features of CJC-1295 No DAC CJC-1295 No DAC / Modified GRF (1-29): Activates the GHRH receptor Stimulates GH release through endogenous pituitary signaling Does not use DAC-mediated albumin binding Has a much shorter duration of action Is more often discussed in research involving pulsatile GH release Why it matters: No DAC is generally used to model shorter GHRH-like signaling, while DAC is used to study prolonged GH-axis activation