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That is, following the example from Table 49, accounting for improper payments occurring in calendar year 2022 might result in the ACO earning greater shared savings (or smaller shared losses) for PY 2022 (because the reduction in ACO PY assigned beneficiary expenditures outweighs the reduction in national and regional expenditures used to update the benchmark), but may result in smaller shared savings (or greater shared losses) for future performance years for which CY 2022 becomes a benchmark year (because the adjustment for improper payments in BY 2022 causes a reduction in the overall benchmark with no corresponding reduction to ACO PY expenditures)

75 , e13988 (2021)

[380] [381] Fabry disease The primary treatment for ocular symptoms arising from Fabry disease, caused by alpha-galactosidase A deficiency, involves using agalsidase alpha or beta (Fabrazyme)

Therefore, the lipid-lowing effects of dietary L-carnitine supplementation in the present study are likely to be caused by increased mitochondrial FA -oxidation activity and decreased lipid synthesis, which was in consistent with some mammalian studies 32,33