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The concomitant activation of crypt-associated signalling pathways mobilises neighbouring epithelial cells to temporarily restore the barrier, and, in the long term, allows the proliferation and differentiation of the ISCs to restore the damaged epithelium [37, 38, 82]

Non-responders are rare (probably under 5%)

2013 paper (PMID: 23055539) has an Expression of Concern issued by the journal in 2021, and the Benoist et al