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For example, rivaroxaban protects the EG against damage caused by oxidative stress (50), doxycycline protects against sepsis-induced EG damage (51), and excessive aldosterone can cause EG damage (52)

However, its high sensitivity in detecting minimal residual disease (MRD) may lead to lower CR response rates, thus hindering comparisons with results obtained by immunofixation at different time points or in other studies [56]

This cationic nature enables strong mucoadhesive interactions and contributes to its potent antimicrobial activity

The study found that FOXO4 localizes predominantly in the cytoplasm of Leydig cells in young mice but translocates to the nucleus in aged animals the same FOXO4-p53 sequestration pattern seen in other senescent cell types