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Acknowledgements The authors would like to acknowledge Kyoto Stock Center, National Institute of Genetics, Vienna Drosophila Resource Center, and Bloomington Drosophila Stock Center for reagents

For instance, in a randomised phase III trial, carboplatin/paclitaxel combination showed clinical benefits but was associated with significant toxicities, including grade 3/4 neutropenia (50%), grade 2 alopecia (86%), neuropathy and hypersensitivity reactions [34]

In our study, we noted the differential regulation of transcripts and metabolites related to the phenylpropanoid and flavonoid pathways between the R and S lines ( Supplementary Tables 2 , 6 )

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