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The TEAEs of cholelithiasis (considered unlikely to be related to omaveloxolone) and hepatic steatosis (considered possibly related to omaveloxolone) were both mild and non-serious and did not result in any discontinuations or changes to drug administration (data on file provided by Biogen)

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The amount of HGF inhibitor that is administered may be in the range of from about 0.1 to about 1,000 mg/kg, an preferably in the range of from about 1 to about 100 mg/kg, although as one of skill in the art will recognize, the precise amount may vary depending on one or more attributes of the drug recipient, including but not limited to: weight, overall health, gender, age, nationality, genetic history, other conditions being treated, etc., and larger or smaller doses are within the practice of this invention