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Libinaka, W

J Clin Endocrinol Metab 105:dgaa267

Because of the association between mutations in UBE3C gene with patients suffering from severe NDD and ASD, we hypothesized that the UBE3C E3 ligase has fundamental roles in the developing brain

For those with significant obesity, referral to a Tier 3 specialist weight-management service or, where clinically appropriate, consideration of bariatric surgery under Tier 4 criteria may be appropriate