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Moore S, Hill EM, Dyson L, Tildesley MJ, Keeling MJ

About 15 percent of adults above 65 years have subclinical deficiency, probably contributed to by the use of H2-receptor blockers for hyperacidity treatment, since these also reduce cobalamine levels

In some research contexts, observations have included mild and transient tolerability-related effects such as: Headaches Nausea Stimulation-related observations Temporary injection-site irritation or localized skin-response variability Research conditions, concentration ranges, dosage ranges, hydration status, administration frequency, and protocol structure may influence tolerability observations across experimental settings