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When we used the catalytically inactive DUSP3-C124S mutant, the KD values for the DUSP3-NPM interaction were still higher for full-length NPM than for the NPM 9122 (Figure 1A, Supplementary Figure 1A, and Supplementary Table 1)

Compared to the previous standard of care, an abstinence-only approach, MOUD is both safe and effective at increasing long-term connection to care, blocking withdrawal symptoms and cravings, decreasing long-term harmful opioid use, and reducing overdose risk [2]