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Choroid plexus and the blood-cerebrospinal fluid barrier in disease

As an illustration, investigations into the impact of 1-methyl-4-phenylpyridinium (MPP+), known for its neurotoxic effects mediated by various mechanisms, including complex I (CI) inhibition, demonstrated elevated glutathione (GSH) levels coupled with the upregulation of ATF-4 and the transsulfuration enzymes CTH and CBS

If iron chelation could induce such pro-inflammatory and pro-glycolytic effects during Mtb infection, then one may expect the opposite to occur with the addition of iron itself

Larvae treated with ALC did not show any significant differences compared to the PTZ group at any of the tested concentrations in the latencies to score 2 and 3 (Fig