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While 100 nM MitoQ only minimally increased DPI-induced cell death ( Figure 1C ), higher MitoQ concentrations significantly enhanced DPI-mediated cell toxicity as measured by an increased PI uptake after 24h, in a MYCN-dependent fashion ( Figure 1E )

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The methionine cycle also comes to a standstill, the level of SAM decreases drastically and the harmful homocysteine increases

visualization, S.K.A