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This interaction is critical in breast cancer oncogenesis and progression, particularly as Bag-1 activity is enhanced by mutant p53, further promoting cell survival and resistance to apoptosis ( Figure 3 ) (57, 58)

[DOI] [PubMed] [Google Scholar] 237.Ezaki O

Exposure to pro-oxidant stimuli usually induces Nrf2 activation and upregulation of antioxidant enzyme expression through binding to the antioxidant response element (ARE), localized in the antioxidant enzyme gene promoters