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This is one reason gentle handling is emphasized

Thurston RC, Kubzansky LD, Kawachi I, Berkman LF

The effect of chronic exposure to waterpipe tobacco smoke on airway inflammation in mice

Activating PTGIR signaling in CD8 + T cells with the prostacyclin mimetic iloprost reduced ATP production from both OXPHOS and glycolysis, which may contribute to both secondary effects on cholesterol biosynthesisalso downregulated by iloprostand T cell dysfunction 40