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AIS: acute ischemic stroke Akt: protein kinase B BBB: blood-brain barrier Ea: electroacupuncture ECM: extracellular matrix GLP-1: glucagon-like peptide-1 GLP-1R: glucagon-like peptide-1 receptor HT: hemorrhagic transformation I/R: ischemia/reperfusion IGF-1: insulin-like growth factor-1 MCAO: middle cerebral artery occlusion miRNA: microRNA MMPs: matrix metalloproteinases MQC: mitochondrial quality control MSCs: mesenchymal stem cells NA-1: nerinetide NBP: 3- N -Butylphthalide NF-B: nuclear factor-kappa B NSCs: neural stem cells NVU: neurovascular unit PI3K: phosphoinositide 3-kinases STAIR: Stroke Treatment Academic Industry Roundtable TCM: traditional Chinese medicine TH: therapeutic hypothermia TIA: transient ischemic attack TLR4: Toll-like receptor 4 The authors would like to express their gratitude to the respective authors and scidraw.io for generously providing the original figure material in this article

In addition, NPs delivery could be facilitated by external stimuli, like magnetic fields or ultrasound

Apply pressure : Pressure is applied to stop bleeding and bandage is placed

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