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Dysregulated activation of NIK or the non-canonical NF-B pathway is associated with lupus-like autoimmune symptoms in animal models

Whereas, in nude mice bearing LNCaP human prostate cancer xenografts, both finasteride and dutasteride has reduced tumor growth, although dutasteride was found to be more effective at an equimolar dose [46]

Side Effects & Safety Injection site reactions -- redness, swelling, stinging (common with large-volume SC injections) Flu-like symptoms -- mild fever, fatigue, malaise 24-72 hours post-injection (possibly from immune clearance of apoptotic cells) GI discomfort -- nausea, mild digestive upset Temporary fatigue -- 1-3 days post-injection Off-target cell death (theoretical) -- no compound is perfectly selective

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