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Reduces Cholesterol levels and Gallstones 5

We refer the reader to section V.H

Combined intestinal loss of PPAR// attenuates KD-driven intestinal stem cell expansion, proliferation and clonogenicity, whereas inhibition of downstream fatty acid oxidation through CPT1A loss limits adenoma formation specifically under KD, linking tumour initiation to fatty acid oxidation of dietary lipids rather than lipid accumulation

ATF4 integrates stress and metabolic signals through heterodimerization with members of the C/EBP family or with nuclear factor erythroid 2-related factor 2 (NRF2) to coordinate adaptive transcriptional programs (80-82)