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Changes in the activation of cytoplasmic E2-initiated signaling cascades were also observed, with decreased phosphorylation of ERK, JNK, and Akt

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Pointing out that riboflavin is a necessary coenzyme for glutathione reductase (one of a chain of enzymes which itself serves to maintain glutathione in the reduced form), they explained that though more research is needed it is likely that a riboflavin deficiency would impact glutathione function and may even impact the levels in the body. The researchers also suggested that vitamin B5 may support glutathione synthesis in the body due to its role in ATP production, while mentioning that vitamin B12 deficiency is linked with low glutathione levels