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Patients with certain medical conditions should exercise caution: those with Leber's hereditary optic neuropathy (a rare genetic condition) may experience optic nerve damage with high-dose cyanocobalamin

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Therefore, the aim of this study was twofold: 1) to assess vitamin B12 serum levels in ME/CFS patients before and after use of high dose vitamin B12 nasal drops and 2) to compare the changes in function before and after starting therapy, using an activity meter, the physical functioning score of the Rand 36 questionnaire, and both the fatigue and concentration scales of CIS20r questionnaire

P= 0.001) or treatment x time interaction (F 32,240 = 4.59