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Thirty-four patients, diagnosed with AIS and receiving reperfusion therapy, were given a dose-escalation of C+P (10/20/50/100 mg) or placebo intravenously at the beginning of endovascular thrombectomy

Comorbidities not primarily involving the vascular system such as diabetes, metabolic syndrome, and lung cancer can be distinguished from those including cardiovascular disease (CVD) [27]

During the interictal period, non-pharmacologic measures as lifestyle changes and the use of reassurance and anticipatory guidance seem to be effective as a preventive treatment

In the liver, insulin inhibits glucose production and release, by blocking gluconeogenesis and glycogenolysis through the regulation of expression of phosphoenolpyruvate carboxylase (PEPCK) [17]