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What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions

However, mechanistic plausibility does not establish clinical benefit, and the current evidence base does not support claims of improved healing, accelerated recovery, or reduced complication rates following orthopaedic surgery

As the first ferroptosis inhibitor to enter preclinical ophthalmic development, Fer-1 eye drops were originally limited by the drugs inherent hydrophobicity

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