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Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease

see Supplementary Note 3)

This trend starts around the same time as fentanyl but really takes off in 2019

J Neurochem 134:720 Orhan N, Ugur Yilmaz C, Ekizoglu O, Ahishali B, Kucuk M, Arican N, Elmas I, Grses C, Kaya M (2016) Effects of beta-hydroxybutyrate on brain vascular permeability in rats with traumatic brain injury