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The microglial responses are designed to engulf cell debris, mediate repair, and reduce the neurotoxic effects of localized necrosis and infiltrating blood components, but may not fully resolve injury, which may promote a perpetuating cycle of microglial activation and BBB injury

The major classes of analgesics include nonsteroidal anti-inflammatory drugs (NSAIDs), opioid analgesics, local anesthetics, and gabapentinoids, each operating via distinct molecular mechanisms yet converging on the suppression of nociceptive signaling at the site of tissue injury, either along peripheral nerves or within central pain-processing pathways

The GSH response with repeated exposures is also very interesting since the level of GSH in the ELF is established at a lower, but still protective level within the first 3 days of CS exposure

Gene expression data were used to contextualize the human generic metabolic network model to represent each of the organoid models used in the study