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Clinical trials have shown promising weight loss results with both medications, but more research is needed, particularly regarding the long-term effects of Tesofensine

doi: 10.2174/1573399818666220418080959

For example, methapyriline increases liver weight and the number of hepatocyte mitochondria in treated mice, with development of hepatotoxicity and liver neoplasia probably secondary to oxidative damage (Powell et al

As such, complex I inhibitors like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or rotenone show preferential cytotoxicity to the DA neurons (Mizuno et al., 1987)