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Dimers enhance activity by linking two molecules of artemisinin, such as a 2-5-fold increase in anti-malarial activity and stronger inhibition of the PI3K/Akt pathway, which can overcome tumor resistance (apc et al., 2021

Bacteria, as natural prokaryotic cells, can actively migrate into the hypoxic TME by their autonomous propulsion and anaerobic properties (Kasinskas and Forbes, 2006)

Prolonged activation of inflammatory pathways in astrocytes and microglia promote demyelination, while their inhibition has the potential to support remyelination in rodents (Jha et al., 2010