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Although not definitively causal, these findings support the biological concern that exogenous antioxidants may attenuate ROS-mediated cytotoxic mechanisms induced by chemotherapy and radiotherapy, potentially reducing treatment efficacy

Engineering a Horseradish peroxidase C stable to radical attacks by mutating multiple radical coupling sites

Rather than reducing demand for orthopedic procedures, these medications may facilitate better patient outcomes, fewer complications, and a shift toward higher-quality, lower-risk surgical care, ultimately benefiting both patients and orthopedic surgeons