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2021 sep 2;184(18):4838-4839]

With regard to the substantial clinical improvement criterion, the applicant asserted that SER-109 represents a substantial clinical improvement over existing technologies because SER-109 treats patients unresponsive to antibiotic treatment for rCDI and can be used in patients ineligible for ZINPLAVA TM due to CHF

Chem Res Toxicol 16:295303 Coen M, Ruepp SU, Lindon JC, Nicholson JK, Pognan F, Lenz EM, Wilson ID (2004) Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse