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Many factors, including radiation, chemicals, viruses, genetic and epigenetic changes, lead to abnormal proliferation of a single cell, which results in the outgrowth of a population of clonal-derived tumour cells

& Innovation Metabolomics: the apogee of the omics trilogy

Japan Association of Molecular Target Therapy Conference, 2012

We further observed that the JE2 thiE mutant with defective thiamine phosphate production was more sensitive than the wildtype JE2 strain to DSF but not DDTC