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The overall survival (OS) and hazard ratios (HR) with 95% CI were assessed by the Kaplan-Meier method using MedCalc software v.19.2.6 (42, 43)

Loss of Lgr5 + stem cells in response to severe (often transmural) injury requires additional regenerative capacities in the intestine, involving quiescent slow-cycling cells located at the +4 position in the crypt, de-differentiated epithelial cells and reserve stem cells 35