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Future clinical research on flavonoids should prioritize larger sample sizes, longer follow-up durations, and multi-center study designs to enhance statistical power and generalizability

discovered that only CCN2 derived from fibroblasts can effectively stimulate the activation of cardiac fibroblasts and promote fibrosis

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de Velasco G, Culhane AC, Fay AP, Hakimi AA, Voss MH, Tannir NM , Tamboli P, Appleman LJ, Bellmunt J, Kimryn Rathmell W, Albiges L, Hsieh JJ, Heng DY, Signoretti S, Choueiri TK