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In particular, NRF2 strongly activates cystine uptake coupled with glutamate excretion and glutathione synthesis, which increases consumption of intracellular glutamate

This limitation caused by the transformation efficiency may be partially overcome by screening the peptide library repeatedly

Its expression is dependent on selenium metabolism and the mevalonate pathway, which generates the isopentenyl pyrophosphate required for the maturation of the selenocysteine tRNA essential for the incorporation of Sec into its catalytic site (4547)

Acamprosate may be safer than baclofen for the treatment of alcohol use disorder in patients with cirrhosis: a first description of use in real-world clinical practice