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Besides, Z-VAD-FMK, an apoptosis inhibitor, scarcely rescued NSBSO-induced cell death in 4T1 cells (Additional file 1: Fig

Figure 3 5.1 Epigenetic regulatory mechanisms EED exposure fundamentally alters the epigenetic landscape through modifications to DNA methylation patterns, histone modifications, and non-coding RNA expression profiles, creating molecular changes that persist across generations and potentially affect offspring health in unprecedented ways

In addition, they found that both the transcript and the protein levels of Nrf2 and the detoxifying/antioxidant enzymes HO1 and NQO1 were significantly decreased [252]