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To imitate the architecture of branched ubiquitin chains conjugated to OTUD5, i.e., distal K48 linkages branching off the proximal K29 linkages, we inserted monoubiquitins into the four K48 residues within a K29-linked tetraubiquitin, resulting in a K29/K48-linked branched octamer (Fig

In contrast, the no loading dose regimen resulted in a gradual increase, reaching a median vitamin B12 concentration of 717 pmol/L after 90 days

Additionally, AL-fed and DL-fed 3xTg mice of both sexes made more errors during the training phases than CR-fed mice (Fig

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